Dendrite enlightenment
2021 | journal article; overview
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Details
- Authors
- Tavosanis, Gaia
- Abstract
- Neuronal dendrites acquire complex morphologies during development. These are not just the product of cell-intrinsic developmental programs; rather they are defined in close interaction with the cellular environment. Thus, to understand the molecular cascades that yield appropriate morphologies, it is essential to investigate them in vivo, in the actual complex tissue environment encountered by the differentiating neuron in the developing animal. Particularly, genetic approaches have pointed to factors controlling dendrite differentiation in vivo. These suggest that localized and transient molecular cascades might underlie the formation and stabilization of dendrite branches with neuron type-specific characteristics. Here, I highlight the need for studies of neuronal dendrite differentiation in the animal, the challenges provided by such an approach, and the promising pathways that have recently opened.
- Issue Date
- 2021
- Journal
- Current Opinion in Neurobiology
- Project
- FOR 2705: Dissection of a Brain Circuit: Structure, Plasticity and Behavioral Function of the Drosophila Mushroom Body
FOR 2705 | TP 6: The role of gap junctions during mushroom body development and remodeling - Working Group
- RG Tavosanis (Developmental Neurobiology)
- ISSN
- 0959-4388
- eISSN
- 1873-6882
- Language
- English