Antibodies Against Glutamic Acid Decarboxylase 65 Are Locally Produced in the CSF and Arise During Affinity Maturation
2023-05 | journal article
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Antibodies Against Glutamic Acid Decarboxylase 65 Are Locally Produced in the CSF and Arise During Affinity Maturation
Biljecki, M.; Eisenhut, K.; Beltrán, E.; Winklmeier, S.; Mader, S.; Thaller, A. & Eichhorn, P. et al. (2023)
Neurology: Neuroimmunology & Neuroinflammation, 10(3) art. e200090. DOI: https://doi.org/10.1212/NXI.0000000000200090
Documents & Media
Details
- Authors
- Biljecki, Michelle; Eisenhut, Katharina; Beltrán, Eduardo; Winklmeier, Stephan; Mader, Simone; Thaller, Anna; Eichhorn, Peter; Steininger, Philipp; Flierl-Hecht, Andrea; Lewerenz, Jan; Kümpfel, Tania; Kerschensteiner, Martin ; Meinl, Edgar; Thaler, Franziska S.
- Abstract
- Antibodies (Abs) against the cytoplasmic protein glutamic acid decarboxylase 65 (GAD65) are detected in patients with neurologic syndromes together referred to as GAD65-Ab spectrum disorders. The response of some of these patients to plasma exchange or immunoglobulins indicates that GAD65-Abs could contribute to disease pathogenesis at least at some stages of disease. However, the involvement of GAD65-reactive B cells in the CNS is incompletely understood.
- Issue Date
- May-2023
- Journal
- Neurology: Neuroimmunology & Neuroinflammation
- Project
- TRR 274: Checkpoints of Central Nervous System Recovery
TRR 274 | C02: In vivo detection and targeting of calcium clearance and axonal membrane repair after acute CNS insults - Working Group
- RG Kerschensteiner (Neuroimmune Interactions)
- eISSN
- 2332-7812
- Language
- English
