Protein-dependent membrane remodeling in mitochondrial morphology and clathrin-mediated endocytosis

2021 | journal article; overview. A publication with affiliation to the University of Göttingen.

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​Protein-dependent membrane remodeling in mitochondrial morphology and clathrin-mediated endocytosis​
Tarasenko, D.   & Meinecke, M. ​ (2021) 
European Biophysics Journal,.​ DOI: https://doi.org/10.1007/s00249-021-01501-z 

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Authors
Tarasenko, Daryna ; Meinecke, Michael 
Abstract
Cellular membranes can adopt a plethora of complex and beautiful shapes, most of which are believed to have evolved for a particular physiological reason. The closely entangled relationship between membrane morphology and cellular physiology is strikingly seen in membrane trafficking pathways. During clathrin-mediated endocytosis, for example, over the course of a minute, a patch of the more or less flat plasma membrane is remodeled into a highly curved clathrin-coated vesicle. Such vesicles are internalized by the cell to degrade or recycle plasma membrane receptors or to take up extracellular ligands. Other, steadier, membrane morphologies can be observed in organellar membranes like the endoplasmic reticulum or mitochondria. In the case of mitochondria, which are double membrane-bound, ubiquitous organelles of eukaryotic cells, especially the mitochondrial inner membrane displays an intricated ultrastructure. It is highly folded and consequently has a much larger surface than the mitochondrial outer membrane. It can adopt different shapes in response to cellular demands and changes of the inner membrane morphology often accompany severe diseases, including neurodegenerative- and metabolic diseases and cancer. In recent years, progress was made in the identification of molecules that are important for the aforementioned membrane remodeling events. In this review, we will sum up recent results and discuss the main players of membrane remodeling processes that lead to the mitochondrial inner membrane ultrastructure and in clathrin-mediated endocytosis. We will compare differences and similarities between the molecular mechanisms that peripheral and integral membrane proteins use to deform membranes.
Issue Date
2021
Journal
European Biophysics Journal 
Project
FOR 2848: Architektur und Heterogenität der inneren mitochondrialen Membran auf der Nanoskala 
FOR 2848 | P05: Molekulare Charakterisierung der MICOS abhängigen mitochondrialen Innenmembran-Biogenese. 
Organization
Institut für Zellbiochemie 
Working Group
RG Meinecke (Molecular Membrane Biology) 
ISSN
0175-7571
eISSN
1432-1017
Language
English

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