RNA polymerase I-Rrn3 complex at 4.8 angstrom resolution
2016 | journal article; research paper. A publication with affiliation to the University of Göttingen.
Jump to: Cite & Linked | Documents & Media | Details | Version history
Documents & Media
Details
- Authors
- Engel, C. ; Plitzko, J.; Cramer, P.
- Abstract
- Transcription of ribosomal DNA by RNA polymerase I (Pol I) requires the initiation factor Rrn3. Here we report the cryo-EM structure of the Pol I-Rrn3 complex at 4.8 angstrom resolution. The structure reveals how Rrn3 binding converts an inactive Pol I dimer into an initiation-competent monomeric complex and provides insights into the mechanisms of Pol I-specific initiation and regulation.
- Issue Date
- 2016
- Journal
- Nature Communications
- ISSN
- 2041-1723
- Language
- English
