Modeling the measurements of cochlear microcirculation and hearing function after loud noise.
2011-09-01 | journal article. A publication with affiliation to the University of Göttingen.
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Modeling the measurements of cochlear microcirculation and hearing function after loud noise.
Arpornchayanon, W.; Canis, M.; Suckfuell, M.; Ihler, F.; Olzowy, B. & Strieth, S. (2011)
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 145(3) pp. 463-469. DOI: https://doi.org/10.1177/0194599811407829
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- Authors
- Arpornchayanon, Warangkana; Canis, Martin; Suckfuell, Markus; Ihler, Fritz; Olzowy, Bernhard; Strieth, Sebastian
- Abstract
- OBJECTIVE: Recent findings support the crucial role of microcirculatory disturbance and ischemia for hearing impairment especially after noise-induced hearing loss (NIHL). The aim of this study was to establish an animal model for in vivo analysis of cochlear microcirculation and hearing function after a loud noise to allow precise measurements of both parameters in vivo. STUDY DESIGN: Randomized controlled trial. Setting. Animal study. Subjects and Methods. After assessment of normacusis (0 minutes) using evoked auditory brainstem responses (ABRs), noise (106-dB sound pressure level [SPL]) was applied to both ears in 6 guinea pigs for 30 minutes while unexposed animals served as controls. In vivo fluorescence microscopy of the stria vascularis capillaries was performed after surgical exposure of 1 cochlea. ABR measurements were derived from the contralateral ear. RESULTS: After noise exposure, red blood cell velocity was reduced significantly by 24.3% (120 minutes) and further decreased to 44.5% at the end of the observation (210 minutes) in contrast to stable control measurements. Vessel diameters were not affected in both groups. A gradual decrease of segmental blood flow became significant (38.1%) after 150 minutes compared with controls. Hearing thresholds shifted significantly from 20.0 ± 5.5 dB SPL (0 minutes) to 32.5 ± 4.2 dB SPL (60 minutes) only in animals exposed to loud noise. CONCLUSION: With regard to novel treatments targeting the stria vascularis in NIHL, this standardized model allows us to analyze in detail cochlear microcirculation and hearing function in vivo.
- Issue Date
- 1-September-2011
- Journal
- Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
- ISSN
- 1097-6817
- Language
- English